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Science & research

Advancing the Science Behind Better Patient Outcomes

CellCore BioSciences is making a sustained investment in the evidence and technology behind better care. We are advancing rigorous clinical research, collaborating with leading academic institutions, and continually investing in our proprietary BioActive Carbon® technology. Together, these efforts are building a growing body of evidence around product safety, efficacy, and mechanisms of action, giving you confidence to make informed decisions and improve patient outcomes.

Evidence in focus

Research Publications

Practitioners need credible clinical evidence to make informed decisions and support better patient outcomes. That’s why CellCore is investing in and supporting clinical research that evaluates our products, expanding a growing body of published evidence, and advancing the science of nutraceutical care.

Cellular study

Under Peer Review

Fulvic and humic acids and mitochondrial respiratory function

University of Memphis · Center for Nutraceutical and Dietary Supplement Research

Tested

BioActive Carbon®

Design

In vitro cell model

Measure

Mitochondrial oxygen consumption rate (OCR)

BioActive Carbon® was evaluated in skeletal muscle cells under induced cellular stress to investigate its effects on mitochondrial respiratory function. Researchers used an advanced, real-time cellular respiration assay to measure mitochondrial function and assess how cells respond to stress. The study also evaluated markers of oxidative stress and antioxidant capacity.

Key finding

Results demonstrated that BioActive Carbon® helped preserve mitochondrial respiratory function under conditions of cellular stress.

Publication pending

Full study results and quantitative findings will be released following peer-reviewed publication.

Cell-based findings do not establish effects in people.

In vitro + cell model

Under Peer Review

BioActive Carbon® contaminant sequestration and intestinal compatibility

Molecules Biolabs · Pennington Biomedical Research Center

Tested

BioActive Carbon®

Design

In vitro + Caco-2 cells

Measures

Contaminant sequestration, cellular compatibility & apparent permeability (Papp)

BioActive Carbon® materials were evaluated for their ability to interact with select environmental contaminants, along with their compatibility and permeability characteristics in an intestinal cell model.

Key finding

Results demonstrated strong contaminant-sequestration activity under controlled laboratory conditions, while providing important insights into how BioActive Carbon® materials interact with the intestinal environment.

Publication pending

Full study results and quantitative findings will be released following peer-reviewed publication.

Cell-based findings do not establish effect in people.

Human clinical trial

Active

Completion Estimated Q1 2027

View Trial Registration

Clinical Trial Evaluating the Impact of a Dietary Supplement Containing Humic and Fulvic Acid on Epigenetic Markers of Biological Age, Detoxification, Inflammation, and Oxidative Stress

TruDiagnostic | ClinicalTrials.gov NCT07579845

Tested

BioToxin Binder®

Design

IRB-registered human trial

Measure

Epigenetic age clocks

A registered 90-day intervention evaluating the impact of BioToxin Binder®, a commercially available dietary supplement containing humic and fulvic acid, on markers of biologic age, detoxification, inflammation, oxidative stress, and related markers among generally healthy adults.

  • 53 active participants
  • 90-day intervention
  • Enrollment complete
  • Initial analysis in progress

Study underway or in development. Results are not yet available.

IRB-approved human study

Active

Completion Estimated Q2 2027

View Trial Registration

IRB-approved practitioner study of systemic toxic burden

Fairfield Family Health · OvationLab

Tested

BioToxin Binder® with Drainage Activator®; CellCore Foundational Protocol

Design

IRB-approved practitioner study

Measure

Systemic toxic burden

An IRB-approved practitioner-setting study evaluating BioToxin Binder® and Drainage Activator® or the Foundational Protocol across systemic toxic-burden measures.

  • 40 patients · 20 per arm
  • IRB approved
  • Practitioner-based setting
  • Led with OvationLab and Chris D’Adamo, PhD

Prospective Human Study Evaluating Changes in Markers of Detoxification, Overall Physical and Mental Health, and Fatigue Following Supplementation With CellCore Protocols | ClinicalTrials.gov

Study underway or in development. Results are not yet available.

The research pipeline

Advancing Evidence through Research

Two active programs and three studies in development extend CellCore research toward measurable human outcomes.

Now

90-day epigenetics trial

53 participants · Completion Q4 2026

Active

Now

IRB-approved practitioner study

40 patients · Expected completion Q1 2027

Active

Next

University-sponsored Human Mitochondrial Trial

12 weeks · Randomized · Placebo-controlled

Development

Next

Bioavailability crossover study

Cellular bioavailability

Development

Next

Mimosa pudica seed mechanistic & GI effects

Translating mechanism to digestive-health outcomes

Development

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Proprietary technology

BioActive Carbon®: The Science

CellCore’s proprietary fulvic and humic acid technology, BioActive Carbon® is formulated to support natural detoxification pathways and mitochondrial function.* Humic acids help bind unwanted compounds, while fulvic acids are smaller, water-soluble molecules that can interact with minerals and other nutrients. Together, fulvic and humic acids help support mitochondrial respiration—a key process in cellular energy production. These complementary actions help promote efficient cellular function and everyday vitality.*

Structure informs function

How BioActive Carbon® Works

Humic and fulvic acids are complementary, and they work differently because of their different structures. Humic acids interact broadly. Fulvic acids move further—creating complementary mechanisms that support detoxification and cellular resilience.*

Scientific illustration of a humic acid molecular structure demonstrating multiple pathways for binding and interacting with compounds. Molecular diagrams highlight electrostatic attraction, hydrogen bonding, chemical binding, and hydrophobic interactions, including examples involving lead and mercury ions. These mechanisms illustrate how humic acids can associate with and sequester a broad range of compounds. Image

Humic

Electrostatic interactionSurface chemical bindingIon exchange

Humic acids: high-capacity sequestration & broad interaction

Humic acids are larger, structurally complex molecules with diverse functional groups. That complexity creates multiple ways to interact with compounds—through electrostatic interactions, hydrogen bonding, hydrophobic interactions, chemical binding and ion exchange.

The takeaway

Multiple interaction pathways allow humic acids to associate with and sequester a broad range of compounds.

Illustration of small water-soluble molecules passing through an epithelial cell layer, interacting with cellular components, participating in redox activity, and supporting mitochondrial function and cellular resilience. Image

Fulvic

Water-solubleMobility & penetrationIon exchange

Fulvic acids: epithelial permeability & cellular support

Fulvic acids are smaller and water-soluble, giving them greater mobility. In our Caco-2 model, the fulvic-dominant material demonstrated measurable epithelial permeability.

The takeaway

Fulvic's smaller, soluble structure allows it to move differently than humic.

Once at the cellular level, fulvic acids can interact with cellular components and participate in redox activity. This provides a mechanistic foundation for supporting mitochondrial function and cellular resilience, which we continue to research.

What Comes Next

Still Asking Deeper Questions

CellCore began by challenging conventional thinking and looking more closely at the systems that shape whole-body health. That curiosity still moves us forward. As science advances and practitioners continue to learn from the people they serve, we’ll keep listening, researching, refining, and building on the approach that brought us here.

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